The similar predictive effect of above four factors had been observed in all-age patients with severe COVID-19. Further analysis showed that severely young adults with two or more factors abnormalities above would be more prone to death. Multivariate logistic regression analysis showed that lymphopenia, elevated level of d-dimer, hypersensitive cardiac troponin I (hs-CTnI) and high sensitivity C-reactive protein (hs-CRP) were independent predictors of mortality in young adults with severe COVID-19. In this retrospective cohort, non-survivors showed higher incidence of dyspnea and co-existing laboratory abnormalities, compared with young survivals in severe COVID-19. The prognostic effects of variables were analyzed using logistic regression model. Clinical characteristics, laboratory findings, treatment and outcomes were obtained from electronic medical records. MethodsĪ total of 77 young adults with confirmed severe COVID-19 were recruited retrospectively at Tongji Hospital. Our study aimed to investigate the clinical characteristics and provide predictors of mortality for young adults with severe COVID-19. Little is yet known whether pathogenesis of COVID-19 is different between young and elder patients.
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